张勇,余权.高效液相色谱法测定包装材料中苯扎氯铵含量[J].包装工程,2017,38(11):60-63. ZHANG Yong,YU Quan.Determination of Benzalkonium Chloride in Packaging Materials by High Performance Liquid Chromatography[J].Packaging Engineering,2017,38(11):60-63. |
高效液相色谱法测定包装材料中苯扎氯铵含量 |
Determination of Benzalkonium Chloride in Packaging Materials by High Performance Liquid Chromatography |
投稿时间:2016-12-05 修订日期:2017-06-10 |
DOI: |
中文关键词: 包装材料 苯扎氯铵 高效液相色谱 |
英文关键词: packaging materials benzalkonium chloride high performance liquid chromatography |
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中文摘要: |
目的 建立高效液相色谱法(HPLC)测定包装材料中3种苯扎氯铵(十二烷基二甲基苄基氯化铵、十四烷基二甲基苄基氯化铵和十六烷基二甲基苄基氯化铵)的含量。方法 将样品经甲醇-水(体积比1∶1)超声,离心过滤,二极管阵列检测器测定,外标法定量。结果 在10.0~500.0 mg/L范围内,3种苯扎氯铵的线性良好,r2≥0.9996,检出限为2.5~5.0 mg/L,定量限为10.0~20.0 mg/L,平均回收率为88.7%~96.6%,相对标准偏差为2.5%~5.3%。结论 该方法前处理简便,灵敏度和准确度高。 |
英文摘要: |
The work aims to establish high performance liquid chromatography (HPLC) to determine the contents of three benzalkonium chlorides (dodecyl dimethyl benzyl ammonium chloride, tetradecyl dimethyl benzyl amm- onium chloride, hexadecyl dimethyl benzyl ammonium chloride) in packaging materials. Samples were extracted by methanol-water (volume ratio 1∶1) ultrasound and centrifugal filtration, determined by diode array detector, and quantified by external standard method. The results showed that three benzalkonium chlorides had good linearity in the range of 10.0~500.0 mg/L, and r2 were less than or equal to 0.9996; the detection limit was 2.5~5.0 mg/L; the limit of quantification was 10.0 ~20.0 mg/L; the average recovery rate was 88.7%~96.6%, and the relative standard deviation was 2.5%~5.3%. The pretreatment of the proposed method is simple, and it is of high sensitivity and accuracy. |
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