文章摘要
张嘉帅,钱静,俞胡斐,崔小波.疫苗温度标签的制备及显色动力学[J].包装工程,2021,42(11):60-66.
ZHANG Jia-shuai,QIAN Jing,YU Hu-fei,CUI Xiao-bo.Preparation and Color Kinetics of Vaccine Vial Monitor[J].Packaging Engineering,2021,42(11):60-66.
疫苗温度标签的制备及显色动力学
Preparation and Color Kinetics of Vaccine Vial Monitor
投稿时间:2020-10-12  
DOI:10.19554/j.cnki.1001-3563.2021.11.009
中文关键词: 疫苗温度标签  2,4-己二炔-1,6-二烷基脲  重结晶  共结晶  活化能
英文关键词: vaccine vial monitor  2,4-hexadiyn-1,6-dialkylurea  re-crystallization  co-crystallization  activation energy
基金项目:国家重点研发计划(2018YFC1603300);无锡科技局产业前瞻与关键技术(现代农业)(N20193008)
作者单位
张嘉帅 江南大学 机械工程学院江苏 无锡 214122 
钱静 江南大学 机械工程学院江苏 无锡 214122 
俞胡斐 江南大学 机械工程学院江苏 无锡 214122 
崔小波 江苏哲勤科技有限公司江苏 无锡 214001 
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中文摘要:
      目的 以2,4-己二炔-1,6-二烷基脲为原料制备疫苗温度标签,并对其重结晶和共结晶的制备,以及显色动力学规律进行研究,为疫苗温度标签的商业化应用提供理论指导。方法 通过使用不同溶剂对2,4-己二炔-1,6-二乙基脲的重结晶,以及不同比例的2,4-己二炔-1,6-二乙基脲和2,4-己二炔-1,6-二丙基脲的共结晶进行实验,确定最适宜的配方,并对其显色动力学规律进行研究,利用分光密度仪对光密度值进行测定,进而通过计算得到反应活化能。结果 不同溶解度的溶剂重结晶2,4-己二炔-1,6-二乙基脲后的固相聚合反应速率不同,通过实验发现以m乙醇∶m水=3∶1的混合溶液为溶剂重结晶,以及mKE∶mKPR=2∶1共结晶得到的产物热反应性较好,颜色变化较为鲜明,且通过计算得到该固相聚合反应的活化能为31.94 kJ/mol。结论 将2,4-己二炔-1,6-二烷基脲作为新型的化学型疫苗温度标签,其视觉响应信号易于识别;通过重结晶和共结晶的改性来匹配不同种类的疫苗,可直观反映疫苗在冷链运输、保存和使用环节的质量。
英文摘要:
      The re-crystallization of 2,4-hexadiyn-1,6-dialkylurea, the preparation of co-crystallization and its color development kinetics were studied, which provided theoretical guidance for the commercial application of Vaccine vial monitor. Through the re-crystallization of 2,4-hexadiyn1,6-diethylurea with different solvents and the co-crystallization test of 2,4-hexadiyn-1,6-bis(ethylurea)(KE) and 2,4-hexadiyn-1,6-bis(propylurea)(KPr) with different proportions, the most suitable formula was determined, and its color development kinetics was studied. The optical density was measured by spectrophotometer.The results showed that the solid-state polymerization reaction rates of recrystallizing 2,4-hexadiyne-1,6-bis(ethylurea) with different solubility solvents were different. Through experiments, it is found that the product obtained by recrystallization with the mixed solution of methanol∶mwater=3∶1 and cocrystallization at mKE∶mKPR=2∶1 has better thermal reactivity and distinct color change, and the activation energy of the solid-state polymerization reaction is calculated to be 31.94 kJ/mol. 2,4-hexadiyn-1,6-dialkylurea is a new chemical time and temperature indicator, and its visual response signal is easy to recognize. Matching different kinds of vaccines by re-crystallization and modification of co-crystallization can directly reflect the quality of vaccines in cold chain transportation, preservation and use.
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