This paper aims to alleviate or solve the problems of cultural relics displays in a single way, the monotonous information introduction, less interactive experience, and failure to fully display the cultural connotation of cultural relics. During the visit, tourists have the problems of blindness, insufficient interest and less gain in the visit. Through combing and practical analysis of the literature of empathy and cultural relics communication, the design process of empathic concept for mobile applications of cultural relics is proposed by using the method of empathy to guide the design of mobile applications for cultural relics communication, “user empathy map” is output by using “participatory empathy observation” and “expression user participation” two empathy research methods; the user's experience of using the product analysis is carried out by using the subjective sentiment assessment scale in the empathy concept, and then the design strategies of cultural relics communication mobile application under the concept of empathy are output. The concept of empathy is put forward innovatively, which is the design process of the mobile application of cultural relics communication, that is, design at three levels:visual layer, interactive layer, and emotional layer, and its design strategy is summarized to promote the development of cultural relics mobile application.