The Jing nationality is the only marine ethnic minority in our country, and its culture is both oceanic and ethnic. Regarding cultural genes as the smallest genetic unit of national culture, this paper aims to construct a map of cultural genes and transforming them into materials for creative design of tourist souvenirs, and establish an evaluation model for tourist souvenirs. This paper attempts to put forward cultural gene duplication method, cultural gene implantation method, cultural gene symbiosis method and cultural gene mutation method on the basis of cultural gene theory to carry out serialized creative design of Jing nationality tourist souvenirs, thereby completing the process of cultural gene map to cultural gene translation. In the design evaluation stage, the analytic hierarchy process and the fuzzy comprehensive evaluation method are integrated to select the best evaluation to determine the priority of product development and clarify the key elements of souvenir design. The cultural genetic design method can strengthen the local and cultural characteristics of tourist souvenirs. The integrated analytic hierarchy process and fuzzy comprehensive evaluation method provides a quantitative basis for the evaluation of the creative design of tourist souvenirs, which overcomes the subjectivity in the process of selecting the best traditional schemes to a certain extent.