In order to satisfy the demands of both aesthetics and comfort of the toilet seat, a comprehensive design method integrating the modeling design and finite element analysis is proposed. Based on the principle of kansei engineering, the design elements of the toilet seat shape were summarized, and 8 types of modeling schemes were initially designed. Then, the semantic difference method was used to evaluate the aesthetics of the designs by means of kansei image, and 4 types of modeling schemes of more beauty were selected and integrated with human body model, which were further analyzed with finite element method to obtain the contact pressure between the human body and toilet seat. Next, the analytic hierarchy process method was taken to comprehensively evaluate the mean value of designs and the pressure value so as to determine the optimal design. Finally, 30 testers were recruited to test the optimal design. The experimental results are close to the finite element analysis, which demonstrates that the comprehensive design method integrating the kansei engineering and finite element analysis is able to assist the designer to design beautiful and comfortable products. Additionally, the paper can also be a reference guide for related designs.