Using the KANO model and research methods related to Kansei engineering, to design a smart household medicine box for the elderly. The KANO evaluation method to analyze the needs of the elderly for the smart household medicine box to sort the priority of the needs through the sensitivity matrix coordinate chart, and the perceptual vocabulary was collected, combined with selection and sorting the perceptual vocabulary through the questionnaire survey method, to establish a product sample database, through which the typical samples was selected with the data obtained by the semantic evaluation method to transform the user's vague perceptual intentions into real and usable data, thus, the design elements was extracted into the design of the elderly smart medicine box. Through the needs of the elderly for smart medicine boxes obtained by the KANO evaluation method and the design elements, such as color, material, shape and function, extracted based on Kansei engineering, the design of the smart household medicine box for the elderly was completed.According to the design process, analyze the special needs of elderly users for medicine boxes, convert the perceptual elements from users' mind into real data, and apply them to design products that truly meet user needs, in which not only should the rational product design elements be considered, but the user's inner perceptual factors should be analyzed to carry out the design practice from the perspective of the target users.