This paper aims to discover and visualize preschool children’s real emotional needs for drug packaging, thus to explore empathy design strategies for children’s drug packaging, and further effectively relieve children’s emotions of drug resistance and parents’ mental pressure to help children take drugs.On the basis of the theory of emotional level, aiming at preschool children’s emotional needs in physiology, psychology, behavior, etc. for drug packaging, a strategic analysis was made in three levels including instinct level, behavior level and reflective level; in combination of domestic and foreign excellent children’s medicine packaging design case analysis, a corresponding children’s empathy drugs packaging design strategy was put forward.The transference of the children’s medicine packaging design based on the three levels of children’s can not noly meet the emotional needs of children, but also enhance emotional communication between medicine packaging and children and parents, thus to encourage children to feel positive emotions to taking medicine, and get a deep perceptual cognition and rational thinking.