Aiming at the status and problems of the existing cultural and creative products of the Anhui Provincial Museum, taking its collection of brick carvings-Baizitu brick carving as an example, this paper researches and innovates cultural and creative products with Anhui regional characteristics, and put forward constructive plan for the cultural and creative design of the Anhui Provincial Museum. By analyzing the cultural value and artistic characteristics of Baizitu brick carving, the product positioning analysis and theme construction are carried out, the implication of Baizitu brick carving pattern is sorted out, and the design practice of Baizitu brick carving cultural and creative products is carried out. Based on the design practice of modelling refinement, color selection, and font composition, a cultural and creative stationery series with teenagers as the main consumer is developed.By exploring the design and application of Baizitu brick carving in cultural and creative products, we will further explore the beauty of Anhui's regional culture and inherit and develop Huizhou brick carving art. The design of cultural and creative products with regional, cultural and practical characteristics will promote the development and innovation of cultural and creative product of Anhui Provincial Museum, and have inspiring significance for the design and practice of cultural and creative products with regional characteristics.