This paper aims to explore the humanization significance and strategy of barrier-free design of food packaging. By summarizing the relevant theoretical concepts of humanized design and barrier-free design, with food packaging design as the base, this paper explores the barrier-free design ideas of food packaging under the humanized design concept from multiple dimensions. The barrier-free design of food packaging should take into account the physiological obstacles such as behavioral function and perceptual function of vulnerable groups. Designers should explore more reasonable unpackaging ways and visual language application methods, dig out the psychological acceptance degree of vulnerable groups, realize interaction through food packaging design, guide consumers to form positive feelings for food packaging, and truly realize the purpose of design to serve people. Humanized design and barrier-free design have commonality, Integrating relevant concepts into food packaging design can coordinate the relationship between products and people, and make the design meet the needs of more consumers (especially vulnerable groups of consumers), which is of great significance to promote equality, inclusiveness, care and respect among human beings.