Under the background of rapid development of intelligent technology and the continuous growth of user requirement, this paper targets to focus on user experience and explore the new form of in-vehicle voice interaction with the "new four modernizations" trend of automotive industry. Also, it aims to reconstruct the in-vehicle voice interaction model and put forward the targeted design strategies. At the first, it discussed the process of information communication between the in-vehicle voice system and user, and proposed the in-vehicle voice interface structure and interaction model. After that, the changes of in-vehicle voice interaction in information subject, range and content under "new four modernizations" trend are summarized, and the in-vehicle voice interaction model as well as design strategies are studied with information processing theory. According to the procedure of information processing in the in-vehicle voice system, the in-vehicle voice interface composed of function layer, content layer, form layer and emotion layer is suggested. And then, models of in-vehicle voice interaction based on information exchanging are constructed. Finally, basing on the theory of voice interface information structure, the strategies of in-vehicle voice interaction design in the future are presented in terms of function expansion, content enrichment, form optimization, and emotion satisfaction. The research of in-vehicle voice interaction design from the perspective of information exchanging is of reference significance to the interaction design and user experience optimization of in-vehicle voice system.