The paper discusses the integration and collaborative innovation of popular science and IP image design from a new innovative angle of view. The paper builds a design and innovation solution model for popular science IP image and uses it to guide the design practice. Around the “Immune Cells” IP image and “Immune Cells Story”, the paper designs a set of popular science IP image system, including interactive program, augmented reality, pop-up books, emoticon, hand book and blind box. The design method for popular science IP image is an innovation and complement to the traditional design process from the new thinking way of integration of popular science, technology and design,so as to adapt to the development of new cultural and creative design in the media convergence era. The method will provide methodology support and practice reference for the upgrade of design methods and design concept, so as offer help to design pluralistic popular science experience and meet the public needs for popular science contents.