This paper conducts a meta-analysis of the impacts of aesthetics experience on user's perceived usability. 22 empirical studies are involved to investigate the impacts of aesthetics experience on user's perceived usability, and three corresponding mediating factors:timing of outcome measures, regional culture and objective usability of product are also examined. Aesthetics experience exerted moderate positive influence on user's perceived usability. Furthermore, the impacts of aesthetics experience on user's perceived usability are more effective before the product usage than that after the product usage; the impacts of aesthetics experience on user's perceived usability ranked first in Asia, then in America, and the last in Europe; and the difference in objective usability of product would also impact aesthetics experience on user's perceived usability to some extent. User's perceived usability always increases with the improvement of aesthetic experience. The influence of aesthetic experience on user's perceived usability is affected by timing of outcome measures, regional culture and objective usability of product, and the differences generated by timing of outcome measures and regional culture are significant.