In order to improve the designer's efficiency in making reasonable decisions in the evaluation stage of ASD children's intervention app navigation interface design and improve the intervention effect of ASD children's intervention app, an evaluation method of ASD children's intervention app navigation interface design based on AHP-entropy weight method is proposed.First of all, through literature analysis and expert evaluation, the evaluation index system of navigation interface design is constructed; Secondly, AHP and entropy weight method is used to determine the weight of each evaluation index respectively; Then, the combination weighting is carried out, and the more reasonable design scheme comprehensive ranking is obtained through weighted calculation; Finally, the evaluation method is applied to the evaluation of 6 design schemes of intervention APP navigation interface. The optimal scheme is selected through the comprehensive calculation of the AHP-entropy weight method, which can better enhance the attention, attraction and guidance of the navigation interface.AHP and entropy weight method are combined to study APP navigation interface for ASD children, which provided a relevant theoretical reference for the design of APP navigation interface for intervention, and provided effective assistance for the selection of teaching staff and decision-making of designers.