This paper isbased on Huizinga's game theory, which has a landmark significance in the game theory field, explores the feasibility, design ideas and specific methods of using game theory to guide the creative practice of package design. This paper systematically reviews and speculates on the origin of game theory, analyzes the definition and elements of game from the perspective of Huizinga. Based on Huizinga's game theory, specific research with two cases of "Time Machine Card" and "Fuhu Garding the House" is carried out on the relationship between Huizinga's game theory and creative package design practice, and the specific application of the three elements of game in the design practice is summarized. This paper concludes how the three elements of game described in Huizinga's game theory, namely voluntary, binding and emotion, are applied to the creative design in a package's structure, situation and visual effect.Huizinga's game theory and creative package design practice have a high degree of consistency, which can provide a new idea and method for creative package design practice from the perspective of game theory.