This paper aims to improve the functionality and practicability of children's OTC drug packaging and to meet the needs of users (both parents and children) , so as to provide new ideas and methods for the innovative design of children's OTC drug packaging in China. Through questionnaire survey and mass interview, we got a deep grip on current users'demand for children's OTC drug packaging. Furthremore, according to the needs of users, we make the OTC drug package plan suitable for children, which provides the theoretical basis for the innovative design of the OTC drug package for children and takes the package of pediatric paracetamol and Huanamin granules as an example. According to the needs of users, the innovation design of OTC drug package for children can be realized from four aspects:interactivity, safety and standardization. In conclusion, the OTC drug packaging for children based on user demand can solve such problems as unclear information transmission, inaccurate dose division of inner-bag drug packaging, unable to alleviate the adverse mood of children's drug use, and missed or repeated applying medicine. Moreover, it provides a strong practical basis for the innovation and development direction of children's OTC drug packaging.