The paper intends to explore new ideas for the inheritance, development and transformation of world heritage culture in Jiangmen Area, and practice the task of cultural and creative cooperation and development burdened by Jiangmen and Hong Kong and Macao as required by the state in the outline of Outline Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area. Through close cooperation with Macao colleges and universities, professional training courses are carried out. Taking Kaiping Diaolou as an example, the paper carries out design research from the humanistic perspective, sorts out the cultural context of Kaiping Diaolou, integrates elements of world heritage culture and the culture behind it into cultural and creative products, thereby enhance the added value of cultural and creative products, and promote the transformation of the local cultural and creative industry structure. The colleges and universities in both regions have organized a stable scientific research team, carried out long-term and effective design training courses, and established a research cooperation relationship with scenic spots, which helps the scenic spots build a business model of production, marketing and research.With cross-regional cooperation of collegesand universities as a platform, cultural and creative products as the starting point, and relying on the resource advantages of Jiangmen and Macao, a new brand image of Jiangmen world heritage culture can be built, which will eventually promote the revitalization of Kaiping world heritage culture.