This paper aims to explore the regional representation in the graphic design. Based on the connotation and extension of regional cultural elements, this paper analyzed the advantages and disadvantages brought by their integration with graphic design, and concluded that it is necessary to integrate and develop them. Then from the specific application methods and analysis, the paper discussed the advantages of regional cultural elements and the profound significance brought about by direct application, indirect application and catering to the times Finally, from the perspective of long-term development, the integration and development of the two were rationally examined, and several practical directions were summarized to further refine the design language and design techniques available for selection. The integration of regional cultural elements into graphic design not only enables the integrated development of modern civilization and traditional culture in the collision, but also brings more novel and culturally meaningful design forms, paving the way for the innovative development of graphic design works with more artistic, practical and cultural characteristics.