This research aims to explore the high-quality development strategy of the Chinese manufacturing industry and the current transformative upgrading path of industrial design. Guided by the concept of the Life-Cycle, the design strategy and design transformation path mode of the high-quality development in manufacturing were discussed from the development status of the manufacturing industry and three development periods of industrial design and manufacturing. Under the guidance of the Life-Cycle concept, the research summarized the Enterprise Design Thinking model of Life-Cycle, the design strategy model of industrial design enabling the high-quality development of the manufacturing, and the manufacturing design transformation path ideas with the Life-Cycle.In conclusion,proceeding from the Design Thinking of the Life-Cycle, six major manufacturing design transformation and high-quality development paths were summarized, namely digital transformation, Life-Cycle management, Life-Cycle evaluation, design service and experience, integration of the whole industry chain, and the new paradigm of design education.