The work aims to explore the user experience design strategy of chronic disease health management APP to improve user retention rate, so that user health can truly benefit from mobile medical health management. Based on the "6A" user experience design model theory, the user experience of interactive behavior of "Add Data" in the "D Nurse" diabetes management APP was optimized. Combined with the analysis on objective level, experience design was carried out from anticipation level, assignment level, behavior level, appearance level and activity level. On this basis, the design strategy of chronic disease management APP with good user experience was summarized. Next, from the functional content level, emotional experience level, interactive operation level and appearance and performance level, the design strategy of chronic disease management APP with good user experience was summed up. According to the design practice, "6A" user experience design model can provide new ideas and perspectives for designing chronic disease management APP with excellent user experience. The design implications are:clear important functions and keep the hierarchy simplified, create a sense of control and convey positive emotions, develop a quick and easy interaction process, uphold moderate functionalism and adopt situational visual language.