The work aims to study the new integration and new ideas of digital cultural creative design of folk museum in view of people's new demand for digital cultural creative design of folk museum in the digital era and the current communication problem of folk culture. The significance and influence of MOE aesthetics on the digital cultural creation of folk museum were analyzed and the characteristics of MOE aesthetics in the physical layer, behavioral layer and conceptual layer were summarized with the help of cultural level division. Then, based on Pierce symbol ternary relation, the connection between MOE aesthetics, folk culture and digital cultural creative design elements and design methods were deeply discussed. With Foshan Zumiao Museum as an example, the digital cultural creation was developed, and the design results were verified. According to the verification data, the digital cultural creation of Foshan Zumiao Museum guided by the digital cultural creative design model of folk museum with MOE aesthetics could enable users to get a better cultural experience. The digital creative design model of folk museum with MOE aesthetics can design the digital cultural creation accepted and loved by people in the digital era, thus providing a reference for the digital cultural creative design of folk museum and then spreading folk culture better.