This paper aims to study the application of the traditional Chinese zodiac "mouse" in red wine packaging design, explore the inheritance and innovation of traditional Chinese zodiac "mouse" in modern red wine packaging design, provide ideas for Chinese zodiac packaging, promote the packaging and development diversification of red wine industry, and find a new direction for inheriting and carrying forward traditional culture. Through the in-depth understanding of the traditional zodiac culture and giving full play to its advantages, analyze and explore the innovative application of the traditional zodiac "mouse" element in red wine packaging from the actual design case "mouse you colorful" series red wine packaging design. The traditional Chinese zodiac packaging has become an increasingly popular cultural phenomenon and artistic expression form, which contains rich cultural spirit and connotation, and also makes the modern packaging design more vigorous and dynamic. The design and re-creation of the zodiac "mouse" element in the field of red wine not only improves the market competitiveness and commercial value of red wine, but also opens up a new path for the inheritance and development of traditional culture and shows the charm and style of Chinese traditional culture.