The work aims to analyze the best works of book design in Jiangsu, explore the cultural characteristics and design innovation of book design under the influence of Jiangnan Culture, and propose innovative strategies for book design today. Typical works of book design in Jiangsu, especially the award-winning works of "Best Book Design from all over the World" were sorted out and the cultural characteristics of book design under the influence of Jiangnan Culture were summarized. The general evaluation methods and innovation dimension of book design, e.g. editorial design, typography, bookbinding and the four standards of best book design from all over the world, etc. were analyzed. The possible dimensions of book design innovation in practice were explained. Book design in Jiangsu is nurtured by Jiangnan poetic culture. It has three cultural characteristics:literati character, hustle and bustle, spirit of craftsmanship. Its design in practice has become a contemporary interpretation of new Jiangnan culture. Based on creation of designer's position, it is concluded that the innovation of book design has four dimensions:affection (high empathy, conveyable affection), intention (intentional ideas, creative inspiration), reasonability (reasonable positioning, high recognition), well-founded (well-founded image, achievable craftsmanship).