The work aims to improve the efficiency and comfort of the existing tower crane cab layout, and propose an optimal design scheme of tower crane cab layout. WSR method was adopted to systematically comb the correlation between various elements from the three dimensions of matter, practical and people. On the matter level, the cab was divided into operating vision area, control area and living area. On the practical level, the driver's behavior process was divided into working behavior and living behavior. On the human level, the driver's needs were divided into physiological needs and psychological needs. The problems at each level were analyzed. The design key points were put forward. The tower crane cab spatial layout optimization design scheme was established. Finally, JACK man-machine simulation method was adopted to verify the rationality of man-machine factors in three aspects:the visibility of driving view field, the accessibility of the upper limbs of the driver's sitting position and the comfort of the driver's control posture. The satisfaction evaluation of cab spatial layout design scheme was investigated with scale scoring. Through detailed and comprehensive analysis of the three levels of matter, practical and people, the main points of the optimized layout design of tower crane cab are obtained, and the spatial layout elements of the existing tower crane cab are reasonably divided and optimized, so as to make effective use of its space and further improve the operator's ease of operation, comfort and fluency. It is verified that WSR method is an effective analysis method for the spatial layout design of tower crane cab, which provides a certain reference for relevant design analysis.