The work aims to accelerate the formation of a new domestic cyclic development pattern and actively explore the path to promote the transformation and upgrading of regional traditional industries. Based on the classic regional brand theory, a brand-driven regional traditional industry analysis framework was established. Based on the case analysis method, with Imabari Towel as an example, the internal mechanism of the traditional towel manufacturing industry in Imabari region of Japan to achieve industrial rejuvenation through brand building were systematically analyzed from three aspects of core brand value, namely, internal integration of the industry, brand image management and communication. As a result, the brand strategy implementation experience with multi-center brand governance, two-way brand drive, and multi-level brand promotion as the core was refined. Brand strategy design has important value in promoting the transformation and development of regional traditional industries. Its significance lies not only in how to establish brand value and brand image promotion and other brand external construction and communication, but more importantly, to provide effective governance methods to strengthen the internal integration of the industry, improve the industrial quality standards and promote industries to advance together. Only in this way can the brand benefit be brought into full play, and can the domestic regional traditional industries be promoted towards high-quality development.