The work aims to analyze the status and progress of the international field of color harmony to provide a basis for further research and design practice. Based on the software Citespace 5.8.R.3, 515 research articles of Web of Science core database from 2001 to 2021 were used as data samples to analyze the international research hot topics and trends of color harmony through the mapping knowledge domains. It was found that the number of research articles issued and the frequency of citations every year had a trend of fluctuating growth from 2001 to 2021. According to the number of their research articles issued and cited, Lichen Ou and Antal Nemcsics were the leading academic authors. According to the number of their research articles issued, Budapest University of Technology & Economics, University of Leeds, National Cheng Kung University and National Taiwan University of Science & Technology were top 4 institutions; and USA, China, England and Taiwan were top 4 countries or regions. The term-based clustering was much better. The field mainly consisted of three hot subjects:mathematical model of color harmony, color emotion and preference, and aesthetic measurement. The color system was the research frontier before 2019, while the color model was the current of the field of color harmony. In conclusion, the field of color harmony gradually attracts the attention of scholars. The building of an academic team is very important to academic output and academic influence. The academic influence of the People's Republic of China needs to be improved greatly.