As a traditional occupant restraint system within a vehicle, safety belts and airbags have been adopted for a long time. Although they have played a positive role in protecting the occupant's safety in crash accidents, there are some disadvantages, especially the lack of effective protection under some special working conditions, which will lead to potential damage. In case of that the demand for autonomous vehicles cannot be fully met in the future, it is necessary to improve and innovate in the occupant protection mode in the interior design because of the various postures and activities of the occupants and the requirements for the comprehensiveness and effectiveness of occupant protection. Based on a review of the traditional vehicle interior wall and the occupant restraint system, a new concept of vehicle interior design based on inflatable wall structure was proposed from the perspective of prototype innovation in interior structure. Then, the innovation of this new concept was sorted out, the preliminary feasibility analysis and demonstration were carried out, the intentional concept of interior was further presented and the follow-up research plan was made. The preliminary simulation analysis indicated that the Head Impact Criteria corresponding to the inflatable wall structure met the international common standards during the collision, which was feasible for the protection mechanism of occupant safety. The vehicle interior based on the inflatable wall structure also realized the environmental protection of vehicle interior from the material level, promoted the lightweight of the vehicle and created a new visual landscape of the vehicle interior. The new concept of vehicle interior based on inflatable wall structure is a revolutionary innovation of traditional vehicle interior wall structure. On the basis of partially retaining the traditional restraint system, a pioneering occupant safety protection mechanism is formed, which is a morphological breakthrough attempt of industrial design of vehicle interior. Combining engineering science and design arts, this exploration will hopefully provide valuable ideas and references for future vehicle interior design.