The work aims to carry out the research on group innovation design in studio teaching mode under the background of new liberal arts construction with respect to the lack of group innovation ability in colleges and universities. By analyzing three typical cases of group innovation design in studio, the main factors of group innovation were summarized:team building, environment creation and tool application. On this basis, the corresponding group innovation design strategy was proposed centering on the studio mode. Through the optimized design project of frame experience, the design strategy was applied to three studio teams, forming three interdisciplinary and cross-background group innovation modes (diversified team mode, open environment mode and online collaborative mode). By the experimental comparison between the three modes and the traditional studio mode, the influence of design strategy on the innovation design ability of studio group was explored and verified. The three design strategies proposed include building a diversified studio team of co-creation and empowerment, creating a social dynamic open studio environment and applying online collaborative sharing studio innovation tool, all of which have a positive influence on the studio group innovation ability and provide a new idea for the research on group innovation design in studio mode under the background of new liberal arts construction.