The work aims to design and develop a transfer machine solution based on Jack virtual simulation evaluation to improve the sense of dignity and comfort of terminally-ill elderly patients, solve their problem of restricted mobility, toileting, bathing, and other living behaviors, and reduce the physical force load of caregivers. Through investigation of existing hospice-assisted mobile products in the market, it was found that the products had problems such as single functional structure, improper operation posture, and limited use environment during the use of the products. The RULA method in the Jack software was used to evaluate the operational posture risk of caregivers. The observation method, interview method and qualitative research method were adopted to study user needs and propose design solutions in combination with man-machine size analysis. Through the above methods, the scheme design of the transfer machine was realized. The design scheme was evaluated for man-machine matching degree, visual field analysis, comfort assessment, and rapid upper limb assessment, which verified the rationality of the design scheme. The design scheme improves the living quality of terminally-ill patients, meets their needs in various scenarios, reduces the workload of caregivers, and provides theoretical and methodological support for subsequent design of the elderly hospice transfer machine.