Carry out multi-dimensional comprehensive evaluation of green packaging, provide specific and systematic packaging optimization basis, and solve environmental problems caused by excessive packaging and discarded packaging. First, establish an evaluation index system covering five attributes of environment, properties of products, innovativeness, economic cost, and user experience, and use ISM to analyze the internal relationship between the indicators and use ANP to determine the weight value, and then divide the packaging grades through gray fuzzy evaluation. Finally, a comprehensive evaluation method is used to obtain the greenness score of the packaging. Comparing the index weight value with the results obtained by the traditional AHP method, it is found that the model of this study is more scientific and reasonable. Taking a wheat husk fresh-keeping packaging design as an example, using the comprehensive evaluation model, the evaluation value of the scheme is obtained as 5.043, and then the packaging optimization direction is proposed according to the score data of the indicators. This research model is suitable for the screening and optimization of various green packaging design schemes, which is helpful for packaging design and production personnel to make scientific decisions, and guides the packaging industry in my country to better transform to a green model.