After the prevention and control of COVID-19 is almost fully released, infected people are mainly treated at home. The work aims to effectively prevent the infected people from infecting other family members through the design strategy of setting up isolation transition space to ensure the normal life of family members and effectively prevent the epidemic. It was proposed to design the indoor functional room for epidemic prevention zoning, take the bedroom as an independent isolation unit, add a transition area at the entrance of the unit, and set up isolation transition space parts that can be easily installed and disassembled from the perspective of the prefabricated concept, and integrate the parts into the intelligent epidemic prevention and disinfection system to reduce the direct contact rate of family members. The parts of the transition space are equipped with fixed parts and adjustable parts. The fixed parts are the skeletons, which plays a supporting role and forms a closed space with the protective film. The adjustable parts are flexible protective films, which are adjustable, which can well connect the parts with the main body of the room opening, and strengthen the isolation effect between the isolation room and other living spaces indoors. It provides new ideas and references for epidemic prevention at home in the post-pandemic era 2.0.