The work aims to alleviate the crisis of physical development of museums after the epidemic, and provide a new way for the digital innovation and development of museums. Firstly, starting from the current situation of the museum industry under the epidemic, the physical difficulties faced by museums were analyzed, and combined with the technical background of the information age, the digital opportunities for the development of museums after the epidemic were clarified. The construction requirements of museum digital culture platform under the epidemic were analyzed from the perspectives of cultural relics, visitors and pavilions. Finally, the framework of the platform was designed by means of digital technology, personalized customization and multi-dimensional interaction. The innovative strategy of digital culture platform framework design of museums after the epidemic was obtained, which realized the expansion of museum traditional exhibitions, the enrichment of personal exhibition experience, the promotion of museum culture communication, and even the expansion of product forms by different sections. The framework of museum digital culture platform can provide new ideas of digital transformation and innovation for the museum industry after the epidemic, and help museums explore new possibilities of digital construction in the future.