The work aims to defuse anxiety and contain rumour-spreading in epidemic prevention and control at present and carry out interactive device design for epidemic prevention and control science popularization to enhance the multi-dimensional experience and emotional interaction of popular epidemic prevention propaganda, and increase the audience's motivation to learn and pay positive attention to epidemic prevention and control. With "installation", an expression medium, as an important epidemic preven-tion and control method, the development trend of integrating video installation with art and popular science education was explored. The application of ultrasonic distance sensors in design of touch interfaces was analyzed. The design of "illness and mouth" installation for popular epidemic prevention propaganda was explored. On this basis, the interactive display of popular epidemic prevention images was realized. The establishment of the popular epidemic prevention image system provides interactive learning means for the public to educate themselves about the epidemic prevention knowledge and control measures, makes the audience feel the novelty of the popular epidemic prevention propaganda, constructs organic connections between epidemic prevention, popular science propaganda, and art, and provides references for spreading epidemic prevention knowledge and conducting epidemic pre-vention education.