The work aims to explore the application of emotional design in the packaging of depression drugs and analyze the role and value of emotional design in the packaging of depression drugs for patients. Based on the theory of emotional design, the case analysis method was used to analyze the emotional needs of patients with depression from three levels:instinct level, behavior level and reflection level, and the emotional design method of drug packaging for depression was analyzed according to the needs of patients for drug packaging. The emotional design of depression drug packaging has high social value and can meet the emotional needs of patients for drug packaging and play a certain imperceptible role in the rehabilitation of patients. Therefore, from the perspective of patients with depression, emotional packaging design is also a good medicine. Designers should change and update their design ideas, take the emotional design theory as the base point, and conduct in-depth research and innovation in packaging positioning, graphics, color and structure design, so as to maximize the function and emotional value of the depression drug packaging and give better medication services to patients with depression.