The work aims to study the elderly-oriented design scheme of on-board interface to improve the experience and safety of elderly users in using on-board human-computer interface. The main factors and obstacles affecting the use of on-board interface by the elderly were summarized through the research on the elderly groups. Through user interviews and preliminary research, the design requirements of elderly users for on-board interface were obtained and classified by Kano model. The user satisfaction of the design requirements was calculated, so as to obtain the key design requirements. According to the relevant results, from the two aspects of visual design and interactive design, the elderly-oriented design scheme of on-board human-computer interactive interface was proposed, and HMI dynamic evaluation method was used to test the usability of practical results. The usability test results of the design scheme show that the elderly-oriented design of the on-board interface by studying the physical deterioration and social cognitive impairment of the elderly can effectively improve the safety and experience of the elderly in using the on-board interface.