The paper aims to propose a meaning-driven design framework for cultural and creative products of museum, and to provide new possibilities for empowering users with positive meanings in museum cultural and creative products nowadays. Firstly, adopting the literature research method to define the concept and current research status of museum cultural and creative product design and meaning-driven design. Secondly, summarizing the meaning dimensions of products based on literature review. Thirdly, proposing a meaning-driven museum cultural and creative product design framework and concept generation algorithm. Finally, doing design practice and design method evaluation through design workshop and providing suggestions for follow-up research. The design framework of meaning-driven museum cultural and creative products includes instinctive meaning to express cultural symbols, enabling meaning to promote emotional construction, and efficiency meaning to enhance community relations. Through the design workshop, 32 museum cultural and creative products were proposed, partially realizing commercial transformation. Applying the meaning-driven design framework to the design of cultural and creative products in museum will help designers effectively carry out innovative design practices.