The work aims to explore how to apply AI generation technology to the design of cultural and creative products in Macao under the background of the digital intelligence era. The campus cultural and creative products of City University of Macau were used as a case study. Based on the semiotic theory of Charles Morris, its cultural symbols were analyzed from three dimensions of semantics, morphology and pragmatics, and a theoretical framework of cultural and creative design was constructed with Midjounery, an AI generation tool. Firstly, the relationship between symbolic signifiers and their meanings was analyzed from a semantic perspective. Secondly, cultural symbols were selected from a linguistic perspective, and their forms were extracted. Then, the extracted symbols were intelligently generated by the AI generation program, Midjourney, to create diverse effects that met user needs. Finally, the intelligently generated symbol elements were combined with product forms to achieve the cultural and creative product design based on the Macau's Portuguese pavement cultural symbols. The design logic of "Symbol Interpretation, Form Presentation, AI Generation, Application, and Promotion" is constructed to take campus cultural and creative product as an example in design application and verify the feasibility of this approach. The results indicate the effectiveness and feasibility of applying AI generation technology to the cultural and creative products design and offers valuable insights and inspiration for promoting the preservation and development of regional traditional culture and interdisciplinary approaches.