The work aims to analyze the innovative design path of compressed oxygen self-rescuers, so as to improve the comfort and interaction efficiency of compressed oxygen self-rescuers. The innovative design process of compressed oxygen self-rescuers was constructed and the product human-computer interaction problems were collected through literature. After these problems were evaluated by the Delphi method, the design factors system was constructed, and three levels of content were sorted out, namely, the way of wearing, the degree of recognition and the way of operation. Based on AHP and DEMATEL methods, the expert opinions were investigated to quantify the comprehensive weight and causality of design factors, and finally obtain their priority. With the wearable way as the core, the innovative design scheme of "triangle back strap wearable" compressed oxygen self-rescuers was proposed. And the scale scoring and the operation timing test were used to investigate the satisfaction of the scheme. The mixed use of the AHP and DEMATEL method can identify factors and output design schemes that are comfort, convenience, and have good man-machine characteristics. The work provides new methods and suggestions for the study of human-computer interaction of compressed oxygen self-rescuers.