The work aims to summarize the guide design principles through user research, build a VR pavilion based on the theme of metal ore in Daye Iron Ore based on the previous research, and verify the virtual reality design guide principle based on handle interaction through design practice. Based on the method of user research and practical design, the design and implementation of VR interactive guidance was carried out by building a VR exhibition hall. The user was invited to conduct a test to evaluate the effectiveness of the pilot design and the feasibility of the plan, and finally the design was optimized according to the evaluation results. Finally, the overall scheme for real-time guide of additional operation help panel was proposed, and the next research idea was proposed for the optimization of the guide process and the humanized guide scheme. Experimental results show that the design scheme can help novice users quickly familiarize themselves with the interactive operation of VR applications in an intuitive and efficient way, reduce learning costs, thereby improving the usability, ease of use and satisfaction of VR application products and upgrading user experience.