The work aims to optimize the design and development of health science videos to enhance users' sustained intention to continue using health science videos and enable designers to accurately grasp users' needs. Based on the C-A-C theory, a theoretical model was constructed to establish the relationship between health science videos, user emotional arousal, and users' intention to continue usage. Structural equation modeling was employed to validate the path relationships among blogger image, expertise, information quality, interaction quality within health science videos, user emotional arousal, and users' intention to continue usage. The findings indicated that blogger image, expertise, information quality, and interaction quality within health science videos had a positive impact on users' emotional arousal and intention to continue usage. Blogger image, expertise, information quality, and interaction quality in health science videos are identified as key factors influencing users' emotional and sustained intention to continue usage. These findings provide valuable insights for designers to improve user emotional arousal and intention to continue usage from a user-centered perspective, and offer theoretical and practical references for the design and innovation of health science video.