The work aims to study the practical application of semiotics in the design of cultural and creative products on Zhuang embroidery, and enrich the cultural connotation and modeling design methods of cultural and creative products on Zhuang embroidery. Based on the O.V.S architecture, the semiotic design method was deduced. Through mining the patterns, symbols and other elements of Zhuang embroidery, the composition of cultural symbols of Zhuang embroidery was classified and extracted. The design path of cultural and creative products on Zhuang embroidery was constructed. The modeling elements of Zhuang embroidery patterns were reorganized through the o.v.s design method. The coding and replacement of Zhuang embroidery symbols were carried out. And the modeling evolution was carried out by means of mirror image, addition, deletion, scaling and rotation to complete the design model expression of cultural and creative products on Zhuang embroidery. The use of semiotics and design methods could effectively excavate the cultural connotation of Zhuang embroidery and provide ideas for the transformation of Zhuang embroidery culture. O.V.S architecture design method can replace two different design objects, so as to produce new object modeling. Combining O.V.S architecture design method with Zhuang embroidery culture can complete the innovative modeling evolution of Zhuang embroidery culture and broaden the design methods and thinking of cultural and creative products.