Under the integrated development of culture and tourism, the work aims to take the local culture and tourism resources of Shaoguan as the research object to construct the design method of cultural and creative products with regional characteristics from the perspective of semiotics, so as to design the cultural and creative products with Shaoguan characteristics and promote the high-quality development of the cultural and tourism industry in Shaoguan. Firstly, the basic theory of semiotics was explained and the constituent elements of visual cultural symbols were analyzed. Then, the cultural and tourism resources in Shaoguan were sorted out and screened, from which the most recognizable and artistic characteristics of the projects were selected. The graphic elements of visual cultural symbols were extracted from the signifier and signified of semiotics and redesigned by means of borrowing and metaphor, so as to form the new signifier and signified of symbols which were applied to the design of cultural and creative products. The design practice plan shows that the design method adopting semiotics is very effective in the design of cultural and creative products with regional characteristics of Shaoguan. This method can create a variety of cultural and creative products, realize the spread of regional culture, and provide a new way for the development and utilization of local cultural resources in Shaoguan.