The work aims to study the innovation of toys for children with nature deficit-disorder based on the AHP-DEMATEL method, and establish a more scientific and reasonable design system to make the design scheme more scientific and comprehensive. Through literature review, user research and expert evaluation, various indicator elements of toy design for children with natural deficit disorder were obtained, and an evaluation indicator model was constructed. AHP and DEMATEL methods were used to evaluate the initial weight of each indicator and the impact weight between each indicator. The initial weight and the influence weight were used to obtain the comprehensive weight, and then the key indicator factors were screened on this basis to carry out design innovation. The results showed that in the design of toys for children with natural deficit-disorder, "natural experience", "human-machine size", "educational nature" and other indicators were the key evaluation criteria, and the design work should focus on these indicators. The use of AHP-DEMATEL method has remarkable significance for the objectivity of the design process, and it can also help researchers obtain more objective and reasonable weight of design elements, which has certain reference value in the field of children's toy design.