The work aims to propose a method of designing cultural and tourism images from regional impressions to design impressions with user impressions as the research guide in the user-centered design context. Longgang in Shenzhen was taken as an example. Firstly, based on the Zaltman metaphor extraction technique, the regional impressions of users were mined, the direction of impression expression was sorted out, and the design representation was determined. Secondly, from the selected regional impression, the design translation was carried out, and the design case was exported by moving forward on two levels:symbolization and imagery. Then, the fuzzy hierarchical analysis method was used to construct a design impression evaluation system to form a professional guide. Finally, users were allowed to evaluate the impressions of the design cases to verify the application satisfaction as well as the feasibility of the study. The method improves the interaction space between user impressions and cultural travel image design, fits the design trend, and optimizes the development and dissemination of regional culture. It is also found in the study that attention should be paid to three points:the precise mining of regional impressions, the improvement of designers' ability and the construction of collaborative design.