The work aims to explore the relationship between the lifestyle change and wheelchair design needs of the youth with acquired lower limb disabilities based on the concern about the their integration into the society, and promote the reconstruction of life confidence of target group through experience design. On the basis of understanding the characteristics of the youth groups with acquired lower limb disabilities and the social integration issues and combined with network text analysis and user interview results, the AIOD lifestyle measurement model was improved, and the measurement dimensions of the group's lifestyle were established. Based on the measurement model dimensions, a questionnaire survey was conducted, and the lifestyle of the group was constructed and subdivided through statistical analysis. Based on the lifestyle measurement results and combined with the CUE experience design framework, the wheelchair experience design opportunity points were output. As a result, the study found that the lifestyle of the youth with acquired lower limb disabilities could be subdivided into positive and optimistic types, stable life types, and negative slack types. From the perspective of inclusiveness of various types, a wheelchair design strategy adapting to diverse lifestyles was proposed. The wheelchair experience was optimized in terms of controllability, effectiveness, ease of use, perception and approval to meet the new needs of life transformation and further promote the formation of positive psychology during the life transformation process.