The work aims to analyze the collaborative innovation of science, art and technology in interactive intelligent packaging design by triple helix theory, expand the coupling interface, enhance the internal evolutionary power of triple helix, and provide new ideas and directions for the sustainable innovative design of intelligent packaging design. Combined with the fuzzy analytic hierarchy process (F-AHP), the research model of the triple helix coupling mechanism of interactive intelligent packaging was constructed, demonstrating that the three aspects of "science-art-technology" maintained their respective ecological cycle, emotional cycle and feedback cycle, and promoted each other through the triple helix of "guidance-algae decoration-support", so as to realize the innovative mode of interactive intelligent packaging design. Through the analysis of the three-dimensional driving force of interactive intelligent packaging by the triple helix coupling mechanism, it explains the three-axis collaborative cross-border integration of "Internet of Everything", "multiple symbiosis", and "performance leapfrogging", which organically integrates the complementary advantages of science, art and technology and the field force formed by fusion drive and cross-innovation, and has a guiding role in the innovation of interactive intelligent packaging design. On this basis, the corresponding design principles and design strategies are proposed to provide theoretical basis and practical guidance for the maximization of the utility of intelligent packaging intelligent design research.