The work aims to systematically understand the global characteristics of the cross-integration research of calligraphy and design, grasp the current research progress and hotspots of the cross-integration of calligraphy and design, and explore the future frontier trend according to the current research progress and hotspots. Based on the journal papers in the cross-integration research field of calligraphy and design collected in CKNI (China National Knowledge Network) database as data sources, VOSviewer and CiteSpace were used to draw a knowledge map from the aspects of the annual publication volume, research institutions, high-yield authors, Keywordco-occurrence clustering, high-citation literature, etc., and visual analysis and review were carried out. The literature output of the cross-integration research field of calligraphy and design is on the rise, and has a rapid growth trend in the past decade. The number of literature in Hunan Normal University and Hubei University of Technology is in the forefront of this field. Research hotspots mainly focus on the application research of calligraphy in packaging and landscape design, font design, graphic design and logo design. The future development direction of calligraphy and design is the mutual cooperation in new technical fields such as artificial intelligence, VR and 3D printing. Lack of deep integration with new technologies, few quantitative studies, lack of theoretical depth and lack of interdisciplinary skills and literacy are the main limitations of the current research.