The work aims to explore how to protect and pass on Yangjiabu woodblock new year paintings, produce a cultural gene map of Yangjiabu woodblock New Year paintings, design cultural and creative products about Yangjiabu woodblock New Year paintings, help China's intangible cultural heritage to follow the development of the society and promote the development of social economy and cultural and creative industries. Firstly, through literature research, field investigation and other research methods, the data of Yangjiabu woodblock New Year paintings were classified and summarized. Secondly, based on cultural genes, morphological factors, color factors, pattern factors and semantic factors of Yangjiabu woodblock New Year paintings were re-extracted and a gene map was drawn. Cultural peripheral products of Yangjiabu woodblock new year paintings such as IP image blind boxes, calendars were generated, which confirmed the feasibility of cultural gene theory to guide the design of cultural and creative products of Yangjiabu woodblock New Year paintings. In conclusion, the cultural gene map sorts out the cultural elements of Yangjiabu New Year paintings, effectively guides the cultural and creative design of Yangjiabu woodblock New Year paintings, and provides references for the inheritance and development of other intangible cultural heritage.