With the continuous development of smart vehicle technology, the in-vehicle information interaction system is becoming increasingly complex. From the perspective of user experience, the work aims to study the usability of intelligent vehicle HMI design by considering aspects such as user needs, driving safety, and operation efficiency to enhance user experience and satisfaction. By systematically analyzing the key points of intelligent vehicle HMI design, a hierarchical index system for intelligent vehicle HMI design was constructed by the Analytic Hierarchy Process (AHP). Weight values were assigned to each index in the system, and three intelligent vehicle HMI schemes were designed. A fuzzy comprehensive evaluation method was employed to evaluate the design schemes. Combined with the evaluation index system, the relatively optimal design scheme for intelligent vehicle HMI was determined, and optimization was performed on the optimal scheme. The results indicate that the Analytic Hierarchy Process effectively hierarchizes the design indexes for intelligent vehicle HMI. When combined with fuzzy comprehensive evaluation to assess the HMI design scheme, it significantly enhances the rationality of design schemes, improves design quality and user experience and provides specific evaluation criteria and reference for intelligent vehicle HMI design and related human-machine interface design.