The theory of Science and Technology Studies (STS) is one of the mainstream theories in the field of philosophy of technology. It has sparked widespread research interest within the design community as it contextualizes design within an extensive social and technological framework. The work aims to systematically review the cross research on STS theory and design, thereby providing insightful perspectives for the field of design. Through a literature review, the perspectives, theories, and methods in STS theory that could be utilized to enhance design research and practice were analyzed and summarized from ontological, epistemological, and methodological dimensions. Furthermore, the relationships among design, technology, and society were delineated from the perspective of STS theory. The inherent socio- constructivist idea in STS theory aids in the in-depth explanation of artificial artifacts and their formative origins, promoting a profound understanding of the designed artifacts and the underlying socio-technical relations. On the ontological plane, STS theory facilitates a reconceptualization of the intrinsic nature of design. Epistemologically, it offers an innovative theoretical framework for analyzing and elucidating the ontology of designed artifacts. Methodologically, it delineates a pragmatic approach for the application of technological solutions to intricate societal and environmental challenges.