The work aims to construct a design method of unmanned cabin space in mobile office scene to improve space utilization and collaboration. The KANO model and AHP model were used to analyze the user's requirements, clarify the priority of functional attributes, and put forward the spatial design strategy. Different spatial structure expansion mechanisms were explored to improve space utilization and balance between privacy and shared space. Based on the "cognitive map" theory, the coordination of spatial layout was optimized, and the corresponding design method and process were put forward. The design department of Shanghai Huamei Elevator Decoration Co., Ltd. was used as the prototype, and the feasibility and effectiveness of the design scheme were verified. The conclusion provides innovative ideas for the design of mobile office space in driverless cars, and provides theoretical and practical reference for future development.